Frontiers | Inflammation, oxidative stress, matrix metalloproteinases and DNA damage in diabetic polyneuropathy and neuropathic pain

The brief

Researchers have identified key factors contributing to diabetic polyneuropathy and neuropathic pain. Diabetic polyneuropathy is a common complication of type 2 diabetes mellitus, causing significant morbidity. The study found that inflammation, oxidative stress, matrix metalloproteinases, and DNA damage play a crucial role in the development of the condition. These factors can lead to nerve damage and pain in diabetic patients. The findings have implications for understanding and treating diabetic polyneuropathy and neuropathic pain.

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